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KMID : 0371319960510020166
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Journal of the Korean Surgical Society
1996 Volume.51 No. 2 p.166 ~ p.173
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p53 Overexpression and Prognosis in Gastric Adenocarcinoma
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Abstract
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With marked development of immunology and molecular biology, great interest have been concentrated on the role of the genes in the carcinogenesis, recently. The gene linked with carcinogenesis was divided into oncogene and tumor suppressor gene.
p53 was
the most widely known tumor suppressor gene. p53 is nucleic phosphoprotein that located on the short arm of chromosome 17 and its half-life becomes longer with a mutation, which allows easier detection due to extended time. The overrxpression of
p53
protein was examined in 31 cases of gastric adenocarcinoma to see the relationship between p53 overexpression and previously known clinicopathologic factors as well as prognosis.
The positive overexpression rate was 45.2%(14 cases), but no statistically significant relationship with clinicopathologic factors was found. The 5 year survival rate that was analysed using the Kaplan-Meier method was 27.5% in positive group and
13.6%
in negative group, which had no statistical differences.
In conclusion it was difficult to say that the p53 protein overexpression alone was the prognostic factor in stomach cancer. Further studies on the relationship between carcinogenesis and cell cycle or DNA ploidy with other gene detection methods
will
be helpful to detect significant prognostic factors.
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KEYWORD
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